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  • d-Dimer Testing in Laboratory Practice | Clinical ...

    2008-5-1 · The pooled sensitivity of the D-dimer test for patients with acute aortic dissection was 327/349, or 94% (95% CI 91–96). Including only those studies in which all acute aortic dissection patients had the D-dimer test, the sensitivity analysis revealed a test sensitivity of 183/192, or 95% (95% CI 91–98) (7, 9, 10, 12, 13, 15). The specificities ranged from 40% to 100%.

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  • Serum D-Dimer is a Sensitive Test for the Detection of ...

    2008-2-1 · The weighted Cohen’s κ for interpretation of the qualitative assay was 0.69 (95% CI 0.63 to 0.76). Conclusions: In this very low-risk ED population, a qualitative D-dimer assay performed at the point of care had similar diagnostic accuracy to the quantitative D-dimer test. Interobserver agreement for the qualitative test was good.

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  • D-dimer testing and acute venous thromboembolism:

    2019-9-5 · “The inclusion criteria were as follows: 1) the study group consisted of patients with breast cancer with a definite diagnosis; 2) the control group consisted of healthy women or patients with benign breast tumors; 3) the D-dimer test method in the study was clear; 4) the study results contained or had sufficient data to calculate the mean and standard deviation, defined here as more than 20 patients; and 5) the study showed a correlation between D-dimer …

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  • Comparison of the Simplify D-dimer assay performed

    2021-5-1 · Since the YEARS algorithm the cutoff level 500 ng/mL is only applied in patients with ≥1 YEARS items and an additional higher D-dimer cutoff level is used in patients without YEARS items, it is relevant to investigate if the differences between the assay performances have an impact on the diagnostic accuracy of the D-dimer test in this setting.

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  • The Clinical Usefulness of D-Dimer Testing in Cancer ...

    2016-11-11 · D-dimer level in cancer patients is associated with risk of venous thromboembolism and deep venous thrombosis. Most cancer patients have “abnormal” D-dimer levels based on the current normal reference range. To investigate tumor-specific D-dimer reference range, we compared D-dimer levels for nine different tumour types with healthy controls by using simultaneous quantile regression …

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  • The association of D-dimer with clinicopathological ...

    2017-5-8 · D-dimer level (expressed in ng/mL fibrinogen equivalent unit: FEU) was measured using an automated latex-based immunoassay (HemosIL D-dimer HS 500); the cutoff level for exclusion of venous thromboembolism was 500 ng/mL. 11 As the detection limit of that D-dimer assay was 203 ng/mL on the ACL TOP analyzers, all test results below that limit were arbitrary assigned this value. When needed, …

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  • Diagnostic accuracy of four different D-dimer assays:

    The answer to this question depends on the validity of the age-adjusted D-dimer studies. The age-adjusted D-dimer for PE Study6 is a classic example of how differential verification bias can affect the test characteristics of the index tests. The investigators recognised the potential for false positivity in older patients, and an age-adjusted D-dimer cut-off could increase the specificity for PE and safely reduce …

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  • D-dimer testing and acute venous thromboembolism:

    The D-dimer test is used to detect the presence of plasmin-mediated degradation products of fibrin that contain cross-linked D fragments. The D-dimer test methodologies used in the 13 studies which formed the basis of the primary analysis in this review were: latex agglutination tests (cut-off values, where specified, 200 to 1,500 ng/mL ...

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  • D-dimer testing for deep venous thrombosis: a

    Reference standard test against which the new test was compared. Studies that compared D-dimer assays with lower extremity ultrasound or venography were eligible for inclusion. Participants included in the review. Studies of symptomatic patients with suspected acute DVT were eligible for inclusion.

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  • The Clinical Usefulness of D-Dimer Testing in Cancer ...

    2008-5-1 · The pooled sensitivity of the D-dimer test for patients with acute aortic dissection was 327/349, or 94% (95% CI 91–96). Including only those studies in which all acute aortic dissection patients had the D-dimer test, the sensitivity analysis revealed a test sensitivity of 183/192, or 95% (95% CI 91–98) (7, 9, 10, 12, 13, 15). The ...

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  • Serum D-Dimer is a Sensitive Test for the Detection of ...

    Results 16 studies were evaluated. Good-quality criteria were reached in 13 out of 16 studies. D-dimer was increased and significantly higher in COVID-19 patients compared with healthy controls, in COVID-19 patients with severe disease or a composite end-point compared with non-severe disease, in ARDS compared with non-ARDS patients and in deceased ARDS patients compared with ARDS patients …

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  • D-dimer as an indicator of prognosis in SARS-CoV-2 ...

    2020-10-28 · The D-dimer test is easily available to detect periprosthetic joint infection (PJI). ... Data extraction and quality assessment. Two reviewers performed data extraction independently, and divergences were negotiated by discussing them with a third reviewer. ... study design, types of operative joints, cut-off of the D-dimer test, total number ...

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  • D-dimer for diagnosis of periprosthetic joint infection:

    2021-1-9 · D-dimer and fibrinogen, both belonging to coagulation parameters, are controversial for the diagnosis of periprosthetic joint infection (PJI). This meta-analysis was conducted to compare their diagnostic accuracies for PJI by synthesizing currently available evidence. Cochrane Library, MEDLINE, Web of Science, and Embase up to March 1, 2020, and other relevant articles were searched.

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  • BET 1: Does a normal D-dimer rule out cerebral

    2021-6-1 · Characteristics of study population. Based on the serum D-dimer level, a four-class grouping was performed, with 62 cases in the Q1 and Q2 groups and 63 cases in the Q3 and Q4 groups.

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  • D-dimer testing as an adjunct to ultrasonography in ...

    1998-10-17 · Objective To investigate the efficacy of using a rapid plasma D-dimer test as an adjunct to compression ultrasound for diagnosing clinically suspected deep vein thrombosis. Design D-dimer concentrations were determined in all patients with a normal ultrasonogram at presentation. Repeat ultrasonography was performed 1 week later only in patients with abnormal D-dimer test results.

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  • D-Dimer Testing for Deep Venous Thrombosis: A

    Abstract. Background: The use of D-dimer assays as a rule-out test for deep venous thrombosis (DVT) is controversial. To clarify this issue we performed a systematic review of the relevant literature. Methods: We identified eligible studies, using MEDLINE entries from February 1995 through October 2003, supplemented by a review of bibliographies of relevant articles.

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  • D-dimer as an indicator of prognosis in SARS-CoV-2 ...

    Results 16 studies were evaluated. Good-quality criteria were reached in 13 out of 16 studies. D-dimer was increased and significantly higher in COVID-19 patients compared with healthy controls, in COVID-19 patients with severe disease or a composite end-point compared with non-severe disease, in ARDS compared with non-ARDS patients and in deceased ARDS patients compared with ARDS patients …

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  • D-dimer and the incidence of heart failure and mortality ...

    2020-8-12 · Conclusions D-dimer was found to be associated with the incidence of HF after hospitalisation and all-cause mortality in patients with AMI. INTRODUCTION D-, a degradation product of cross-dimer linked fibrin, might serve as a marker of thrombogen-esis and a hypercoagulable state following plaque rupture.1 Moderately high levels of D-dimer have

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  • D-dimer levels on admission and all-cause mortality

    2020-9-7 · D-dimer level on admission is a promising biomarker to predict mortality in patients with COVID-19. In this study, we reviewed the association between on-admission D-dimer levels and all-cause mortality risk in COVID-19 patients.

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  • Excluding venous thromboembolism using point of

    2009-8-14 · Cardiac D-dimer seems to be the only test with the capacity to exclude DVT in patients with a moderate pre-test probability (up to 27%; fig 4), although only four studies on Cardiac D-dimer were available and thus the 95% confidence interval exceeds 2%. The decision on which point of care D-dimer test to use depends on the setting.

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  • Frontiers | D-Dimer-Driven Anticoagulation Reduces ...

    2021-2-4 · Objective: Examine the possible beneficial effects of early, D-dimer driven anticoagulation in preventing thrombotic complications and improving the overall outcomes of COVID-19 intubated patients.Methods: To address COVID-19 hypercoagulability, we developed a clinical protocol to escalate anticoagulation based on serum D-dimer levels. We retrospectively reviewed all our first 240 intubated ...

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  • Diagnostic accuracy of conventional or age adjusted D ...

    2013-5-3 · Objective To review the diagnostic accuracy of D-dimer testing in older patients (>50 years) with suspected venous thromboembolism, using conventional or age adjusted D-dimer cut-off values. Design Systematic review and bivariate random effects meta-analysis. Data sources We searched Medline and Embase for studies published before 21 June 2012 and we contacted the authors of …

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  • d -Dimer elevation and adverse outcomes | SpringerLink

    2014-7-9 · d-Dimer is a biomarker of fibrin formation and degradation. While a d-dimer within normal limits is used to rule out the diagnosis of deep venous thrombosis and pulmonary embolism among patients with a low clinical probability of venous thromboembolism (VTE), the prognostic association of an elevated d-dimer with adverse outcomes has received far less emphasis.

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  • Dynamic changes of D-dimer and neutrophil

    2020-7-3 · Dynamic changes of D-dimer, NLR and other laboratory tests. The associations between dynamic changes in D-Dimer, NLR and infection markers, cardiac injury index and hospitalization days were shown in Table 3.It could be found that there was a strong correlation between D-Dimer, NLR and other markers (P < 0.05).The test showed a stronger correlation between hospitalization days, PCT and peak D ...

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  • D-Dimer: Not Just an Indicator of Venous Thrombosis

    2014-7-1 · Background Plasma D-dimer levels have been shown to be high in advanced tumor stage patients and can be used to predict clinical outcome in cancer patients. As most advanced tumor stage patients exhibit asymptomatic metastasis, which contributes to early tumor recurrence after surgery, we hypothesized that plasma D-dimer levels can be used to predict patients with potential metastasis.

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  • current role and future prospects of D-dimer

    Abstract. D-dimers have been discovered as by-products of fibrinolysis. In situations where the fundamental pathology is associated with increased thrombolytic activity, D-dimer assays could serve an integral role in the clinical workup, and have an already established role in the diagnosis of clinical disorders of venous thromboembolism, and disseminated intravascular coagulation.

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  • Excluding venous thromboembolism using point of

    2009-8-14 · Cardiac D-dimer seems to be the only test with the capacity to exclude DVT in patients with a moderate pre-test probability (up to 27%; fig 4), although only four studies on Cardiac D-dimer were available and thus the 95% confidence interval exceeds 2%. The decision on which point of care D-dimer test to use depends on the setting.

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  • D-Dimer Is Associated With First-Ever Intracerebral ...

    2018-7-25 · Spearman rank-order correlation was used to test correlations between D-dimer levels and traditional cardiovascular risk factors. P values <0.05 (2-sided) were considered significant. The D-dimer concentration was analyzed as both a continuous variable, per SD, and a categorical variable in tertiles.

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  • Utilization of serum D-dimer assays prior to computed ...

    2021-1-19 · A variety of evidence-based algorithms and decision rules using D-Dimer testing have been proposed as instruments to allow physicians to safely rule out a pulmonary embolism (PE) in low-risk patients. To describe the prevalence of D-Dimer utilization among emergency department (ED) physicians and its impact on positive yields and utilization rates of Computed Tomography Pulmonary …

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  • Do Normal D-dimer Levels Reliably Exclude Cerebral

    2004-10-28 · The D-dimer levels (mean±SD) were significantly higher in patients with CST than in patients in whom CST could be excluded (2052±1286, 375±368, respectively; P <0.0001). From the 35 neuroradiologically proven CST cases, there was only 1 (2.8%) who had a normal D-dimer …

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  • Association of Level and Increase in D‐Dimer With All ...

    2021-1-8 · D‐dimer, which is a fibrin degradation product, is a biomarker for coagulation and reflects increased thrombosis. 6, 7 Although D‐dimer level has been clearly confirmed to be associated with death in the general population in the long term, 8, 9 only a few studies assessed the association of D‐dimer with death 10, 11, 12 or poor ...

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  • Second trimester maternal serum D-dimer combined

    2021-3-2 · This study investigated whether maternal serum D-dimer (DD) alone or DD combined with alpha-fetoprotein (AFP) and free β-subunit of human chorionic gonadotropin (free β-hCG) in the second trimester could be used to predict hypertensive disorders of pregnancy (HDP). In this retrospective case–control study, the data of gravidas patients who delivered at hospital were divided into the ...

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  • The DiPEP study: an observational study of the

    2018-5-21 · We therefore planned to test a threshold for positivity for D-dimer using the hospital laboratory threshold during the first trimester, 1.5× the laboratory threshold for the second trimester and 2× the laboratory threshold for the 3rd trimester, based on data showing how D-dimer levels increase during pregnancy 12 and evidence that a higher ...

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  • D-dimer levels on admission and all-cause mortality

    2020-9-7 · D-dimer level on admission is a promising biomarker to predict mortality in patients with COVID-19. In this study, we reviewed the association between on-admission D-dimer levels and all-cause mortality risk in COVID-19 patients.

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  • DULCIS (D-dimer and ULtrasonography in

    2009-8-7 · D-dimer is performed at the time of anticoagulation suspension. If above or below age and gender specific cut-offs, anticoagulation is stopped and D- dimer repeated after 15, 30, 60 and 90 days. Other Name: D-dimer, fibrin fibrinogen degradation products

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  • Improvement in plasma D-dimer level in severe SARS

    2021-4-16 · They developed rising D-dimer levels to a peak of 13.21 μg/ml FEU and >20.0 μg/ml FEU, respectively, which dropped to 1.34 μg/ml FEU 8 days later in Patient 1 and to 2.94 μg/ml on hospital day 13 in Patient 2. In Patient 3, the D-dimer level on admission was found to be elevated to >20.00 μg/ml FEU together with imaging evidence of thrombosis.

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  • Association of Level and Increase in D‐Dimer With All ...

    2021-1-8 · D‐dimer, which is a fibrin degradation product, is a biomarker for coagulation and reflects increased thrombosis. 6, 7 Although D‐dimer level has been clearly confirmed to be associated with death in the general population in the long term, 8, 9 only a few studies assessed the association of D‐dimer with death 10, 11, 12 or poor ...

    Get Price
  • Cureus | Higher Admission D-Dimer Values Are

    2019-11-18 · If the test system’s calibration procedure includes three or more levels of calibration material, and includes a low, mid, and high value, and is performed at least once every six months, then the requirement for calibration verification is also met.

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  • Clinical Laboratory Improvement Amendments (CLIA)

    The closer the curve follows the upper left-hand corner and the larger the area under the curve, the better the test is at discriminating between those with and without the disease. AUC is a global measure of diagnostic accuracy. The area under the curve may be any value between 0 and 1 and it is a good indicator of the overall quality of the test.

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  • DVP&R | Design Verification Plan and Report | Quality

    2015-12-25 · performed on the finished product, all components (APIs and excipients) along with containers/closures <1226> targets primarily analytical tests for drug products and APIs, but its principles of verification could also be applied to test methods for …

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